Answer:
As we know enzymes are specific for different reactions and The conditions required by an enzyme to function are also specific. An enzyme which works in a basic environment will not be able to function in a acidic environment.
If the pH for a reaction is increased from 2 to 11 then this change will change the active site of the enzymes. As a result, the substrate will not be able to fit into the enzyme and hence the enzyme will not catalyze the reaction.
